Mice lacking the methyl CpG binding protein 2 (MeCP2) that is known to cause Rett syndrome (Amir et al., 1999), show social avoidance (Moretti et al., 2005) and a mPFC specific dysfunction of excitatory neurotransmission (Sceniak et al., 2015). This evidence concerns the gene MECP2 and Rett syndrome.