One of the main neurodegenerative disorders caused by VLCFA is the X-linked adrenoleukodystrophy (X-ALD) (Kruska et al., 2015), associated with the loss of peroxisomal ABCD1 fatty-acid transporter function and VLCFA accumulation (Galea et al., 2012). Here, ABCD1 is linked to X-linked adrenoleukodystrophy.