We have previously found that SOCE in SK-N-SH human neuroblastoma cells is enhanced due to the expression of full-length mutant huntingtin (Glushankova et al., 2010; Wu et al., 2011), whereas, according to Tang et al. (2003), the expression of exon 1 of mutated huntingtin (Htt138Q-1exon) alone is sufficient for enhancing the affinity of IP3R to IP3. The gene discussed is HTT; the disease is neuroblastoma.