WFS1 and Wolfram syndrome: The Wfs1 protein has long been implicated in the generation of its titular disease, Wolfram Syndrome, which is an inherited autosomal recessive neurodegenerative disorder (Inoue et al., 1998; Hardy et al., 1999; for review see Rigoli et al., 2011) associated with visual/auditory sensory atrophy and also significant diabetic pathophysiologies.