In contrast to these bimodal KEGG pathways, many signaling pathways associated with neural activity were specifically upregulated (gap junction, long-term depression and potentiation, Parkinson's disease, and adherence junction), while the pathways populated by downregulated transcripts were strongly related to metabolic stress responses (p53 signaling pathway, peroxisome, complement and coagulation cascades, and ribosome biogenesis in eukaryotes; Figure 3B). This evidence concerns the gene TP53 and Parkinson disease.