Advances in genetic engineering and fundamental research applied to a better understanding of the biology of ErbB signaling in cancer have led to the development of many therapeutic agents including monoclonal antibodies (mAbs), small-molecule TKIs and other agents like peptides, affibodies, nanobodies, etc. (Bennasroune et al., 2004b; Alaoui-Jamali et al., 2015). This evidence concerns the gene EGFR and cancer.