RHOA and Hypertension: The underlying mechanism for the enhanced RhoA/ROCK signaling in hypertension was shown to be a consequence of the upregulated renin-angiotensin-aldosterone system (Seko et al., 2003; Moriki et al., 2004; Wirth et al., 2008; Guilluy et al., 2010), and an increased production of reactive oxygen species (Sun et al., 2008).