In a recent study, Lundius et al. (2013) examined the effect of GPR37-GFP overexpression on cytotoxicity mediated by three cytotoxic treatments that mimic components of PD: MPTP (a precursor to MPP+, an inhibitor of complex I that leads to mitochondrial dysfunction), rotenone (also causes mitochondrial dysfunction, leads to Lewy body-like aggregates) and 6-OHDA (forms reactive oxygen species and activates the UPR). Here, GPR37 is linked to Parkinson disease.