MTOR and Alzheimer disease: In addition, mTOR is associated with clearance of Aβ, synaptic remodeling, long-term potentiation (LTP), and cognitive decline (Jaworski et al., 2005; Paccalin et al., 2006; Hoeffer and Klann, 2010; Ma et al., 2010), indicating its predominant roles in AD development.