Furthermore, the administration of NaHS attenuated anxiety-like behaviors and the deficit of spatial learning and memory associated with increases in plasma H2S, antioxidation, anti-inflammation, BACE1, and pS9-GSK3β as well as with decreases in amyloid deposition, tau hyperphosphorylation, and reactive gliosis in the footshock-stimulated 3×Tg-AD mice. This evidence concerns the gene BACE1 and Alzheimer disease.