TARDBP and amyotrophic lateral sclerosis: Mouse/Rat—Strong ALS-like phenotype in G93A, G37R, G85R, and D90A; variable severity across entity of SOD lines; H4R and G93A do not exert classical ALS; no TDP-43 abnormalities observed in many lines (Carri et al., 2015) Worm—Some of the cellular and molecular hallmarks of clinical ALS phenotypes (Therrien and Parker, 2014)