Alternatively, it has been observed that TDP-43 stabilizes the RNA of human low molecular weight neurofilament protein via interaction with the 3′UTR, altering its location in spinal MNs and thereby possible favoring the formation of NF aggregates in ALS (Strong et al., 2007) and mitochondria mis-localization. Here, TARDBP is linked to amyotrophic lateral sclerosis.