In line with this, the p75 neurotrophin receptor (p75NTR) has been associated with ALS-associated MN death, as nerve growth factor (NGF) secreted by mSOD1 astrocytes induced death of p75NTR expressing MNs via the formation of NO and peroxide (Pehar et al., 2004). The gene discussed is NGF; the disease is amyotrophic lateral sclerosis.