While this pathway was found activated in presymptomatic ALS mice as well (Raoul et al., 2006), it is noteworthy that mSOD1 astroglia produce significant NO and FasL (Barbeito et al., 2004), thus implying that astroglia could in fact be the executioner of MN death in ALS. This evidence concerns the gene FASLG and amyotrophic lateral sclerosis.