Mutations in transactive response (TAR) DNA-binding protein (TARDBP or TDP43; Kabashi et al., 2008) and fused in sarcoma/translocated in liposarcoma (FUS/TLS, ALS6; Kwiatkowski et al., 2009; Vance et al., 2009) have been linked to fALS. Here, TARDBP is linked to sarcoma.