hiPSCs—ALS MND phenotype variations, excessive MN death vs. enhanced vulnerability and dendrite alterations; TDP-43 proteinopathy and cytoplasmic aggregates, astrogliosis (Bilican et al., 2012; Egawa et al., 2012; Serio et al., 2013; Tsao et al., 2012). Here, TARDBP is linked to mild neurocognitive disorder.