Interestingly, the mouse model described in Imielski et al. (2012) is a phenocopy of Alzheimer's disease (AD) in three aspects: reduced NF-κB activity as in AD brains (Kaltschmidt et al., 1999), increased proliferation of immature DCX+ neuronal precursors, and progressive cell loss (Jin et al., 2004) coupled with strong neuroinflammation. This evidence concerns the gene NFKB1 and early-onset autosomal dominant Alzheimer disease.