RPS6KB1 and neuropathy: Thus, by interfering in the LKB1/AMPK/mTOR/S6K1 pathway, Metformin seems to be a promising drug in the field of neuro-oncology whereby it can destroy cancerous brain cells and their CSCs (Carmignani et al., 2014), revitalize healthy neurons, and even prevent chemotherapy-induced neuropathy (Mao-Ying et al., 2014).