The predominance of the CRF2 downstream signaling pathway in the mediation of nesfatin-130−59's anorexigenic action might result from reduced processing of POMC to α-MSH under conditions of obesity due to reduced prohormone convertase two levels (Çakir et al., 2013). The gene discussed is NUCB2; the disease is obesity due to melanocortin 4 receptor deficiency.