TNF and Sepsis: In Gram-negative sepsis IL-6 and TNF-α showed the best AUC values (both 0.93); in Gram-positive sepsis the best AUC was found for IL-6 (0.91); in yeast sepsis IL-6, IL-8, and IL-10 showed the highest AUC values (0.92 for all) (Table 4).