At the ROC analysis, APACHE II resulted to be less accurate in differentiating severe sepsis/septic shock patients from nonsevere sepsis (AUC = 0.69) than SOFA score (AUC = 0.91), whereas MR-proADM had an intermediate accuracy (AUC = 0.79) between APACHE II and SOFA scores, as shown in Figure 5 and Table 6. This evidence concerns the gene BTBD8 and Sepsis.