CXCR4 and neoplasm: The combination of AMD3100 with bevacizumab further inhibited tumour growth (Fig. 7e), angiogenesis (Fig. 7f) and fibrocyte-like cells recruitment (Fig. 7g), suggesting that CXCR4 inhibition could partially overcome the development of bevacizumab resistance by inhibiting the re-angiogenesis mediated by fibrocyte-like cells.