SMC3 and breast cancer: rs5913992 is also within the region of the binding sites of six overlapping transcription factors (transcription factor binding sites)—RELA, CTCF, CEBPB, RAD21, ZNF143, and SMC3—that were detected by ChIP-Seq analysis in lymphoblastoid, epithelial, endothelial, breast cancer, and myeloid leukemia cell lines (Fig. 3).