In one study in patients with sciatica, a TNF-alfa inhibitor (eternacept) infiltrated on the nerve root was more effective than dexamethasone at 1 month [37], in another study in patients with lumbar stenosis, anti-interleukin 6 infiltrated on the nerve root was more effective than dexamethasone at 1 month [38]. The gene discussed is IL6; the disease is Sciatica.