At variance, the trend of increase in CD4/CD8 ratio at T3 (0.73 ± 0.08 versus 0.46 ± 0.04) was maintained at T6 (0.71 ± 0.08) and T12 (0.74 ± 0.09) in IMMD Group. This evidence concerns the gene CD4 and autosomal dominant mitochondrial myopathy with exercise intolerance.