Although one model is generally indicated that Ifng-AS1(NeST) was required for Ifng expression in response to infection with Salmonella, and Ifng-AS1(NeST) was found to bind WDR5 component of histone H3 lysine 4 methytransferase complex, and to modify H3K4me3 at the Ifng locus by CD8+ T cells30. The gene discussed is CD8A; the disease is infection.