To address the mode of action, of how reduced ALDH1A2-RAR signaling impacts tumor-related processes, FaDu cells were cultured in the presence of the ALDH1A2 inhibitor WIN18.446 or BMS493, an inverse agonist of pan-RAR, which induces nuclear co-repressor interaction with RARs. The gene discussed is ALDH1A2; the disease is neoplasm.