Since SLE, like many other autoimmune diseases, affects females more frequently than males, at a rate of almost 9 to 1 [10], we independently analyzed the 152 female patients (92.7%) out of the total of 164 SLE patients recruited in the study, in order to find out if gender has an important role in the high susceptibility of the GABRP SNPs and SLE. The gene discussed is GABRP; the disease is autoimmune disease.