These analyses revealed that positive cystatin A expression, T classification, and N classification were independent prognostic factors of OS in NPC patients; T classification was an independent prognostic factor of LRFS; and age ≥ 45 years, N classification, and positive MIP-3α expression were also independent prognostic factors of DMFS (Table 2). The gene discussed is CSTA; the disease is nasopharyngeal carcinoma.