Due to the sparse knowledge on the association of adipokines with clinical characteristics of MS, the purpose of this two-year prospective follow-up study was to assess whether the levels of adiponectin, adipsin, leptin, and resistin in plasma of MS patients are associated with clinical phenotypes, inflammatory disease activity, neurological disability, and the volumes of T1-weighted and fluid attenuation inversion recovery (FLAIR) lesions on magnetic resonance imaging (MRI). This evidence concerns the gene CFD and myeloid sarcoma.