Similarly, the Münster Heart Study has reported dyslipidemias to be the factor most tightly correlated with coronary events, and HDL-C concentration in particular appears to be an important predictor of atherosclerotic disease [45, 46], in harmony with findings from the INTERHEART Study, which has also reported dyslipidemias—especially low HDL-C—to be key predictors of CVR, based on estimations with ApoB/ApoAI index [47]. This evidence concerns the gene APOB and metabolic syndrome.