Tumor-specific methylation of ADAMTS19 was significantly more frequent in gastrointestinal than in gynecological cancers (odds ratio (OR) = 2.9, confidence interval (CI) = (1.9–4.7), p = 5.2 × 10−7) and was independent of the methylation of adjacent loci in CRC. Here, ADAMTS19 is linked to colorectal carcinoma.