However, notwithstanding a putative independent role of FBN2 in CRC, we conclude that FBN2 is not the main target for inactivation because of the following considerations: Methylation of this gene is not specific for tumor cells as it shows some weaker methylation in normal tissue, which is not the case for ADAMTS19 (Fig. 2). This evidence concerns the gene ADAMTS19 and neoplasm.