GCG and hydrops fetalis: While chronic treatment with sitagliptin led to peak active GLP-1 levels of around 50 pM after a meal challenge which rapidly declined within 2–3 h in HF-DIO mice [40], evogliptin 0.081% led to mean ambient GLP-1 levels of 10.3±1.01 pM (3.7 fold greater compared to HF-DIO control).