BKM120, a 2,6-dimorpholino pyrimidine derivative, is an orally available pan-Class I PI3K inhibitor currently in clinical trials for solid tumors (Maira et al., 2012; Bendell et al., 2012; Brachmann et al., 2012) and may represent a novel therapeutic agent for PIK3CA-related epilepsy. This evidence concerns the gene PIK3CA and epilepsy.