Activating mutations in genes of PI3K-AKT signaling pathway, especially PIK3CA, encoding the catalytic p110α isoform of the PI3K complex, have long been linked to cancer (Cheung and Testa, 2013; Engelman, 2009; Hennessy et al., 2005; Iwabuchi et al., 1995; Samuels and Waldman, 2011; Gymnopoulos et al., 2007). The gene discussed is AKT1; the disease is cancer.