Previous studies have reported significant associations between HLAG polimorphisms (in particular the +2960 14-bp INDEL) and cancer risk [30,34], but to the best of our knowledge, this is the first study indicating a role for HLA-G 3’UTR regulatory SNPs in DFS and OS after adjuvant treatment of CRC. The gene discussed is HLA-G; the disease is colorectal carcinoma.