Considering the relevance of the 3’UTR region in the control and regulation of the HLA-G transcripts and the lack of data in literature, our purpose was searching for associations between HLA-G 3’UTR polymorphisms detected at the germinal level, and the disease free survival (DFS) and OS of stage II-III CRC patients in adjuvant regimen. This evidence concerns the gene HLA-G and colorectal carcinoma.