As endogenous negative regulators, CIS/Socs family inhibits LPS-induced inflammatory cascades with different mechanisms.36, 37 For example, increased Socs3 could inhibit inflammatory response by suppressing the JAK2/STAT3 signaling pathway in the caerulein-induced AP model.20 In this study, we examined the expression patterns of all eight CIS/Socs family members, and found that the levels of Socs1 and Socs3 expression were increased most significantly after LPS treatment in mice acinar cells. Here, CISH is linked to alkaline phosphatase measurement.