JAK2 and alkaline phosphatase measurement: As endogenous negative regulators, CIS/Socs family inhibits LPS-induced inflammatory cascades with different mechanisms.36, 37 For example, increased Socs3 could inhibit inflammatory response by suppressing the JAK2/STAT3 signaling pathway in the caerulein-induced AP model.20 In this study, we examined the expression patterns of all eight CIS/Socs family members, and found that the levels of Socs1 and Socs3 expression were increased most significantly after LPS treatment in mice acinar cells.