As the only Traf family member which participates in signal transduction of the tumor necrosis factor (TNF) receptor superfamily and the interleukin-1 receptor (IL-1R)/TLR superfamily, Traf6 has been demonstrated to be involved in regulating cell death, survival, and cellular responses to stress.7 Deletion of Traf6 paralyzed NF-κB signaling and downregulated the productions of TLRs induced-cytokines.8, 9 Our previous study has shown that there is a correlation between the TLR4-Traf6 signaling and the severity of pancreatic inflammation in a mouse model with mild AP induced by caerulein. Here, TRAF6 is linked to alkaline phosphatase measurement.