Of interest, in MYCN-amplified tumors without TERT rearrangements the expression of TERT was nevertheless increased compared with low-risk NB owing to the known function of MYCN as transcriptional activator of TERT.21 The expression of TERT was greatly increased in TERT-rearranged NBs compared with the low-risk group. The gene discussed is MYCN; the disease is Nijmegen breakage syndrome.