A real breakthrough in the search for genomic alterations that impact on NB aggressiveness comes from the recent observation of telomerase reverse transcriptase (TERT) activation by genetic rearrangements in high-risk NB.20 By whole-genomic sequencing of 59 NB cases the authors discovered recurrent genetic rearrangements in the chromosomal region 5p15.33 proximal of TERT. Here, TERT is linked to neuroblastoma.