ALK and neuroblastoma: More recently, activating mutations of ALK were reported in both familial and sporadic cases of neuroblastoma.10, 11, 12, 13 In familiar NB, germline mutations in ALK gene have been found in ~50% of the cases.13 In addition, some sporadic NB acquire somatic mutations of ALK and ~2% display genomic amplification of the gene as reviewed in (ref. 14).