MDM2 and neuroblastoma: p53, although rarely mutated in NB, is destabilized in MYCN-amplified tumors by the high expression of its ubiquitin ligase MDM2.22 Furthermore, p53 pathway is often deranged in NB cells that lack MYCN amplification but display telomere lengthening activity.23 In the next paragraph we will discuss the role of p53 family and the detrimental effect(s) that its alteration may cause in NB.