MDM2 and neuroblastoma: Indeed, aberrant expression of MYCN had a positive effect on pro-angiogenic factors, including angiogenin and VEGF, and MYCN amplification correlates with poor survival, increased dissemination and high vascularization in NB.45 In this scenario, MYCN amplification might stimulate tumor vascularization and dissemination by also inhibiting the anti-angiogenic activity of TAp73 either directly or via MDM2.