Indeed, upon hypoxia ΔNp73 is stabilized and capable of inducing the expression of VEGF-A, the prototypic angiogenic gene.58 Similarly to ΔNp73, ΔNp63 is also able to increase the vascular endothelial growth factor (VEGF) secretion by leading to the stabilization of the HIF-1α protein.59 Therefore, these data suggest a cross talk between the p53 family members and the tumor angiogenesis pathways, potentially involved in the regulation of NB vascularization. The gene discussed is VEGFA; the disease is neoplasm.