ConA-triggered STAT3 phosphorylation and BNIP3 induction requires a JAK/STAT signaling has been reported in mesenchymal stromal cells and glioblastoma cells.44, 45 However, further studies are required to understand whether or which JAKs are involved in ConA-mediated STAT3 phosphorylation of human hepatoma cells. This evidence concerns the gene STAT3 and hepatocellular carcinoma.