In this instance, we observed that in Purkinje cells the lack of Hipk2 negatively interferes with Wnt/β-catenin proper function, giving rise to an impaired degradation of β-catenin – a hallmark of Parkinson's disease, spinocerebellar ataxia, and other neurodegenerative diseases. This evidence concerns the gene HIPK2 and neurodegenerative disease.