We speculate that the 14-amino acid NLS sequence is available for binding when TG2 is in open conformation, and ACR might induce the conformational change in TG2 enabling it to specifically enhance nuclear accumulation of TG2 in ACR-treated HCC cells by enhancing the TG2/importin-α/importin-β trimeric complex formation. Here, TGM2 is linked to hepatocellular carcinoma.