VEGFA and neoplasm: The stemness status of the former is maintained by endothelial cells via nitric oxide and Notch activation [3,6,15], whereas GSCs/progenitors would activate endothelial cells to proliferate, eliciting angiogenesis through vascular endothelial growth factor (VEGF) (Figure 2), to host at the tumor the BM-derived endothelial precursor cells (EPCs) promoting their differentiation into blood vessels inserted into the pre-existent vasculature [4].