The exogenous expression of GLI1 did not increase expression of hTERT in non-malignant cells; however, downregulation of GLI1 and GLI2 in human colon cancer, prostate cancer and glioblastoma multiforme by C-terminus truncated GLI3 repressor mutant (GLI3R), or by GANT61, reduced hTERT protein expression (Figure 3) [84]. The gene discussed is GLI1; the disease is Familial prostate cancer.