The increase of blood coagulation factors such as fibrinogen and plasminogen activator inhibitor (PAI)-1, and decrease of anti-coagulation factors such as antithrombin III (AT-III) and protein C occurred in diabetic patients cause hypercoagulability, and favor the development of thrombosis, stroke, myocardial infarction, and/or glomerulosclerosis [15,16]. The gene discussed is SERPINC1; the disease is glomerulosclerosis.