Finally, thanks to several sensitive assays to measure anti-gluten T response in blood cells, as IFN-γ ELISPOT/ELISA or tetramers-flow cytometry technologies, it is thinkable to apply this innovative approach to clinical practice, in order to help specialists in making a correct and definitive diagnosis of celiac disease in those cases in which subjects are arbitrarily on gluten free diet, or can help the diagnosis in case of potential celiac disease. The gene discussed is IFNG; the disease is celiac disease.