CD8A and Cowden disease: Despite the central role given by HLA class II in CD, being the main genetic risk factor and the key restriction molecules of pathogenic CD4+ T-cells, studies from our group have demonstrated that gliadin contain peptides able to stimulate cytotoxic CD8+ T-cells in an antigen restricted manner when presented on surface of antigen presenting cells (APC), such as B- or enterocytes by HLA class I molecules [52].