Trials conducted in individuals with T2D had all participants treated with oral glucose-lowering agents (4 trials [15,16,30,33]), some treated with either oral glucose-lowering agents, insulin or both (3 trials [13,24,31]), all treated with insulin (1 trial [29]), or all treated with diet and lifestyle alone (1 trial [32]); otherwise information on the use of oral glucose-lowering agents or insulin was unspecified (2 trials [14,23]). Here, INS is linked to type 2 diabetes mellitus.