TP53 and lung carcinoma: Our data revealed that TP53 was the most frequent pathogenically-mutated gene [30,31], and all patients harbored the SNP rs1042522 in TP53. Interestingly, this SNP, responsible for a substitution of a proline residue with an arginine residue in codon 72 of TP53, has been associated with lung cancer susceptibility [32] and a risk of toxicity during platinum-based chemotherapy treatment in advanced NSCLC patients [33].