As an example, the inactivation of Akt/mTOR/S6 pathway is required for an increase in pancreatic cancer cells apoptosis and tumor growth inhibition by thymoquinone pretreatment following gemcitabine treatment synergistically [34].A very recent study also shows that resveratrol synergistically enhanced the antitumor effects of erlotinib in non-small-cell lung cancer cells by inhibiting the Akt/mTOR/S6 pathway [35]. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.