In estrogen receptor α (ERα)-positive (ERα(+)) cancer cells, 3,3-bis(4-hydroxyphenyl)-7-methyl-1,3-dihydro-2H-indol-2-one (BHPI) rapidly hyperactivates plasma membrane PLCγ, generating IP3, which opens EnR IP3R calcium channels, rapidly depleting EnR Ca2+ stores [18]. This evidence concerns the gene ESR1 and cancer.