Our data is consistent with previous study that DAG/PKC/ERK pathway is involved in the development of glomerular dysfunction in diabetes [40], our finding of the reduced p-ERK by the depletion of PKCδ suggests the existence of DAG/PKCδ/ERK pathway in PLCγ1-driven cell proliferation and migration of human gastric adenocarcinoma cells. Here, PRKCD is linked to gastric adenocarcinoma.