TNFSF10 and coronary artery disorder: On one hand, evidence has shown that there is an inverse relationship between the serum sTRAIL concentration and the severity of coronary arterial disease [12, 33, 37], indicating that the increased TRAIL production may act as a compensatory mechanism that regulates the disrupted homeostasis of lipid metabolism under pathological conditions, and may prevent the development of resultant vascular lesions.