In this context, the present work demonstrates that the mammalian “obesogen” TBT -reported to increase adipose mass and induce NAFLD in mammals through the activation of PPARγ and RXR [17–19]- perturbs the energy reserves and transcriptional regulation of lipid metabolism in the model teleost zebrafish following chronic exposure to very low and environmentally relevant concentrations. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.