Thus, triglycerides administration in the brain of rats stimulates insulin secretion and down-regulates hepatic glucose production [77] and induction of obesity-related hormones such as leptin and ghrelin in the brain repress or stimulate, respectively, the transcription of enzymes involved in FA de novo synthesis in the liver and adipose tissue [78]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.