PON1 and laryngotracheoesophageal cleft: The pathogenic mechanism linking oxidative stress and hepatocarcinogenesis has previously been studied.34,35 PON1, one member of the PON family, plays a crucial role in antioxidant defense and anti-inflammatory.11,12 Sun et al36 reported that the expression levels of PON1 protein in patients with LC and HCC were significantly lower than that in the healthy controls.