PON1 and cancer: The 192Gln variant seems to induce higher PON1 hydrolytic activity towards paraoxon19,20 and to be more effective than 192Arg in the prevention of LDL oxidation.21 For, several studies have looked at the correlation between the rs662 SNP and the risk of various cancers, such as ovarian epithelial carcinoma,22 brain astrocytoma and meningioma,23 lymphoma,24 and lung cancer,25 in various populations.