It has been suggested that the variant alleles of PON1 rs662 and rs705382 seem to induce higher PON1 activity.19,20,27 However, there are fewer studies investigating the association of the PON1 rs662 and rs705382 polymorphism with CHB and LC, as well as with HCC. Here, PON1 is linked to laryngotracheoesophageal cleft.