Taking it even a step further, a common inversion in human chromosome 3 in leukemia patients between GATA binding protein 2 (GATA2) and ecotopic viral integration site 1 (EVI1) repositions a GATA2 enhancer near EVI1 leading to its ectopic expression while reducing GATA2 expression [65], thus achieving a “two for the price of one” tumorigenesis affect (Fig 3A). Here, GATA2 is linked to leukemia.