Only a more recently published study reported that HER-2 overexpression was correlated with more distant metastasis in rectal cancer.28 This correlation might be attributed to the HER-2 functions in cell proliferation, adhesion, and migration.6 Gene expression analysis revealed that the E2F transcription factors were integral to the development and progression of HER-2 positive tumor.29 This evidence concerns the gene ERBB2 and neoplasm.