ERBB2 and adenocarcinoma: For both rectal and gastric cancers in gastrointestinal tract, their biological characters are similar in many ways, that is they are adenocarcinoma with high rate of liver metastasis and effective chemotherapy regimen.16,17 Given the predictive value of HER-2 protein with response to trastuzumab in gastric cancer, it is interesting to study the HER-2 positivity in rectal cancer.