MiR-218 matures from miR-218-1 and miR-218-2, 2 loci of which were located within the introns of SLIT2 (4p15.31) and SLIT3 (5q35.1), respectively.9 Wu et al12 reported that reduced expression of miR-218 was associated with worse survival of lung cancer. The gene discussed is SLIT3; the disease is lung cancer.