High expression of LRIG1 correlates with better patient survival in multivariate analyses where other known risk factors were included.4,10,17,18 Studies have demonstrated that the LRIG1 expression is associated with human papillomavirus (HPV) status.10 LRIG1 is an independent positive prognostic marker patients with HPV-positive tumor.10 In the II A–II B and nonsmoker groups, LRIG1 expression did not correlate with patient's overall survival (Fig. 5). Here, LRIG1 is linked to neoplasm.