Kereszturi et al found that the c.194 + 2T > C intronic mutation abolished SPINK1 expression at the mRNA level and increased the risk of chronic pancreatitis by diminishing protective trypsin inhibitor levels.37 No study has yet elucidated the detailed pathway of the intron mutation altering and impacting the function of pancreatic stellate cells, acinar cells, and islet cells. This evidence concerns the gene SPINK1 and chronic pancreatitis.