Studies from our group has convincingly demonstrated that a SPINK1 intron mutation (c.194+2T>C, OMIM ∗167790) was most commonly found among all currently seen mutations with a much higher incidence rate and no occurrence in healthy controls.19,20 By analyzing data from all ICP populations and in juvenile ICP patients, we found that the SPINK1 c.194+2T>C mutation may correlate with an earlier onset of diabetes, as well as a higher rate of presence of pancreatic stones. The gene discussed is SPINK1; the disease is diabetes mellitus.