PNPLA3 and hepatocellular carcinoma: Meta-analysis, a statistical method to contrast and combine results from different studies, is widely used to uncover the masked or underestimated SNP-cancer associations reported in single studies.32 In view of a less precise measure of interest caused by small samples of the identified studies, we performed a meta-analysis with an aim to achieve a higher statistical power for the association between ADPN I148M polymorphism and HCC risk.