PTEN−/− NSC-derived neoplasm also expressed typical mixed markers of GBM including Nestin, SRY box 2 (SOX2), glial fibrillary acidic protein (GFAP), neuron-specific beta -III tubulin (Tuj1) and microtubule-associated protein 2 (MAP2) (Fig. 2g)33, 34. This evidence concerns the gene SOX2 and glioblastoma.